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Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone
BACKGROUND: Bone metastasis is the most common metastatic destination in advanced breast cancer, presenting a poor prognosis and clinical challenges in management. To date, the mechanism of bone metastasis in breast cancer remains largely unclear. METHODS: Differentially expressed genes in primary t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168524/ https://www.ncbi.nlm.nih.gov/pubmed/35685372 http://dx.doi.org/10.1016/j.csbj.2022.05.051 |
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author | Sui, Laijian Sanders, Andrew Jiang, Wen G. Ye, Lin |
author_facet | Sui, Laijian Sanders, Andrew Jiang, Wen G. Ye, Lin |
author_sort | Sui, Laijian |
collection | PubMed |
description | BACKGROUND: Bone metastasis is the most common metastatic destination in advanced breast cancer, presenting a poor prognosis and clinical challenges in management. To date, the mechanism of bone metastasis in breast cancer remains largely unclear. METHODS: Differentially expressed genes in primary tumours that developed bone metastases were systematically analysed using both TCGA-BRCA and E-MTAB-4003 databases. Adaptive phenotype in the subsequent bone lesions was analysed in the GSE46161 database. A series of biomarkers including homing, immune escape, angiogenesis, and factors involved in both osteoblastogenesis and osteoclastogenesis were included to dissect the molecular events underlying bone metastasis in breast cancer. RESULTS: Upregulated expressions of GDF11 expression is positively correlated with colonization, osteoblastogenesis and osteoclastogenesis, whilst CD151 is positively associated with angiogenesis and immune escape. PAFAH1B2 expression is inversely correlated with the angiogenic process. Reduced YTHDF2 may facilitate cancer cell homing, osteoclastogenesis and immune escape in breast cancer. DPP9, FAS, ZNF519, RPP14 and FAU were evaluated for their potential involvement in for the homing to bone, escaping from immune surveillance, angiogenesis, osteoblastic activity and osteoclastic activity in the multi-step process of bone metastasis. CONCLUSION: GDF11, CD151, PAFAH1B2 and YTHDF2 may play a pivotal role in the predisposition of metastasis to the bone from breast cancer, whilst DPP9, FAS, ZNF519, RPP14 and FAU may be actively involved in the adaptative colonisation of metastatic breast cancer cells in bone. |
format | Online Article Text |
id | pubmed-9168524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-91685242022-06-08 Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone Sui, Laijian Sanders, Andrew Jiang, Wen G. Ye, Lin Comput Struct Biotechnol J Research Article BACKGROUND: Bone metastasis is the most common metastatic destination in advanced breast cancer, presenting a poor prognosis and clinical challenges in management. To date, the mechanism of bone metastasis in breast cancer remains largely unclear. METHODS: Differentially expressed genes in primary tumours that developed bone metastases were systematically analysed using both TCGA-BRCA and E-MTAB-4003 databases. Adaptive phenotype in the subsequent bone lesions was analysed in the GSE46161 database. A series of biomarkers including homing, immune escape, angiogenesis, and factors involved in both osteoblastogenesis and osteoclastogenesis were included to dissect the molecular events underlying bone metastasis in breast cancer. RESULTS: Upregulated expressions of GDF11 expression is positively correlated with colonization, osteoblastogenesis and osteoclastogenesis, whilst CD151 is positively associated with angiogenesis and immune escape. PAFAH1B2 expression is inversely correlated with the angiogenic process. Reduced YTHDF2 may facilitate cancer cell homing, osteoclastogenesis and immune escape in breast cancer. DPP9, FAS, ZNF519, RPP14 and FAU were evaluated for their potential involvement in for the homing to bone, escaping from immune surveillance, angiogenesis, osteoblastic activity and osteoclastic activity in the multi-step process of bone metastasis. CONCLUSION: GDF11, CD151, PAFAH1B2 and YTHDF2 may play a pivotal role in the predisposition of metastasis to the bone from breast cancer, whilst DPP9, FAS, ZNF519, RPP14 and FAU may be actively involved in the adaptative colonisation of metastatic breast cancer cells in bone. Research Network of Computational and Structural Biotechnology 2022-05-30 /pmc/articles/PMC9168524/ /pubmed/35685372 http://dx.doi.org/10.1016/j.csbj.2022.05.051 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Sui, Laijian Sanders, Andrew Jiang, Wen G. Ye, Lin Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
title | Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
title_full | Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
title_fullStr | Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
title_full_unstemmed | Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
title_short | Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
title_sort | deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168524/ https://www.ncbi.nlm.nih.gov/pubmed/35685372 http://dx.doi.org/10.1016/j.csbj.2022.05.051 |
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