The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. Driven by the unmet need to develop better therapies for KMT2A-rearranged leukemia, we previously discovered that the novel anti-...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Lin, Karsa, Mawar, Ronca, Emma, Bongers, Angelika, Kosciolek, Angelika, El-Ayoubi, Ali, Revalde, Jezrael L., Seneviratne, Janith A., Cheung, Belamy B., Cheung, Laurence C., Kotecha, Rishi S., Newbold, Andrea, Bjelosevic, Stefan, Arndt, Greg M., Lock, Richard B., Johnstone, Ricky W., Gudkov, Andrei V., Gurova, Katerina V., Haber, Michelle, Norris, Murray D., Henderson, Michelle J., Somers, Klaartje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168530/
https://www.ncbi.nlm.nih.gov/pubmed/35677155
http://dx.doi.org/10.3389/fonc.2022.863329

Ejemplares similares

Ejemplares similares