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Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH

Opening of two-pore domain K(+) channels (K2Ps) is regulated by various external cues, such as pH, membrane tension, or temperature, which allosterically modulate the selectivity filter (SF) gate. However, how these cues cause conformational changes in the SF of some K2P channels remains unclear. He...

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Detalles Bibliográficos
Autores principales:	Tsai, Wen-Hao, Grauffel, Cédric, Huang, Ming-Yueh, Postić, Sandra, Rupnik, Marjan Slak, Lim, Carmay, Yang, Shi-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168622/ https://www.ncbi.nlm.nih.gov/pubmed/35500647 http://dx.doi.org/10.1016/j.jbc.2022.101998

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