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Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway

Inactivation of the VHL tumor suppressor gene is the signature initiating event in clear cell renal cell carcinoma (ccRCC), which is the most common form of kidney cancer. The VHL tumor suppressor protein marks hypoxia-inducible factor 1 (HIF1) and HIF2 for proteasomal degradation when oxygen is pre...

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Detalles Bibliográficos
Autores principales:	Stransky, Laura A., Vigeant, Sean M., Huang, Bofu, West, Destiny, Denize, Thomas, Walton, Emily, Signoretti, Sabina, Kaelin, William G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168943/ https://www.ncbi.nlm.nih.gov/pubmed/35357972 http://dx.doi.org/10.1073/pnas.2120403119

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