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Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment

Transforming growth factor‐β (TGF‐β) and programmed death ligand 1 (PD‐L1) initiate signaling pathways with complementary, nonredundant immunosuppressive functions in the tumor microenvironment (TME). In the TME, dysregulated TGF‐β signaling suppresses antitumor immunity and promotes cancer fibrosis...

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Detalles Bibliográficos
Autores principales:	Gulley, James L., Schlom, Jeffrey, Barcellos‐Hoff, Mary Helen, Wang, Xiao‐Jing, Seoane, Joan, Audhuy, Francois, Lan, Yan, Dussault, Isabelle, Moustakas, Aristidis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168966/ https://www.ncbi.nlm.nih.gov/pubmed/34854206 http://dx.doi.org/10.1002/1878-0261.13146

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