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Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era

SARS-CoV-2 very often causes kidney involvement through various mechanisms including: acute tubular injury, virus cell invasion, vascular damage due to hypercoagulability and finally dysregulation of the immune system. Even though there are no pathognomonic morphologic features that can rule out or...

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Detalles Bibliográficos
Autores principales: Papalia, Giuliana, Barbuto, Simona, Campus, Anita, Vischini, Gisella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169020/
https://www.ncbi.nlm.nih.gov/pubmed/35666373
http://dx.doi.org/10.1007/s40620-022-01351-8
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author Papalia, Giuliana
Barbuto, Simona
Campus, Anita
Vischini, Gisella
author_facet Papalia, Giuliana
Barbuto, Simona
Campus, Anita
Vischini, Gisella
author_sort Papalia, Giuliana
collection PubMed
description SARS-CoV-2 very often causes kidney involvement through various mechanisms including: acute tubular injury, virus cell invasion, vascular damage due to hypercoagulability and finally dysregulation of the immune system. Even though there are no pathognomonic morphologic features that can rule out or confirm direct damage by SARS-CoV-2, the latest literature suggests that there may be some association. SARS-CoV-2 infection represents a poor prognostic factor, regardless of pulmonary involvement. We report a challenging case with complex renal biopsy findings suggestive of collapsing glomerulopathy and focal proliferative IgA-dominant glomerulonephritis in a patient affected by active hepatitis C virus (HCV), SARS-CoV-2 infection and personal history of cocaine abuse.
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spelling pubmed-91690202022-06-07 Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era Papalia, Giuliana Barbuto, Simona Campus, Anita Vischini, Gisella J Nephrol Case Report SARS-CoV-2 very often causes kidney involvement through various mechanisms including: acute tubular injury, virus cell invasion, vascular damage due to hypercoagulability and finally dysregulation of the immune system. Even though there are no pathognomonic morphologic features that can rule out or confirm direct damage by SARS-CoV-2, the latest literature suggests that there may be some association. SARS-CoV-2 infection represents a poor prognostic factor, regardless of pulmonary involvement. We report a challenging case with complex renal biopsy findings suggestive of collapsing glomerulopathy and focal proliferative IgA-dominant glomerulonephritis in a patient affected by active hepatitis C virus (HCV), SARS-CoV-2 infection and personal history of cocaine abuse. Springer International Publishing 2022-06-06 2023 /pmc/articles/PMC9169020/ /pubmed/35666373 http://dx.doi.org/10.1007/s40620-022-01351-8 Text en © The Author(s) under exclusive licence to Italian Society of Nephrology 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Report
Papalia, Giuliana
Barbuto, Simona
Campus, Anita
Vischini, Gisella
Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era
title Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era
title_full Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era
title_fullStr Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era
title_full_unstemmed Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era
title_short Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era
title_sort double glomerulopathies or two-faced janus? a challenging case in the covid-19 era
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169020/
https://www.ncbi.nlm.nih.gov/pubmed/35666373
http://dx.doi.org/10.1007/s40620-022-01351-8
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