The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid–sensing TLRs and ligands to endolysosomes

A function-impairing mutation (feeble) or genomic deletion of SLC15A4 abolishes responses of nucleic acid–sensing endosomal toll-like receptors (TLRs) and significantly reduces disease in mouse models of lupus. Here, we demonstrate disease reduction in homozygous and even heterozygous Slc15a4 feeble...

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Detalles Bibliográficos
Autores principales: Rimann, Ivo, Gonzalez-Quintial, Rosana, Baccala, Roberto, Kiosses, William B., Teijaro, John R., Parker, Christopher G., Li, Xiaohong, Beutler, Bruce, Kono, Dwight H., Theofilopoulos, Argyrios N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169117/
https://www.ncbi.nlm.nih.gov/pubmed/35349343
http://dx.doi.org/10.1073/pnas.2200544119

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