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Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions

OBJECTIVES: Our aim in this study was to evaluate the systemic endothelial dysfunction status and carotid intima-media thickness (CIMT) in patients with retinal vein occlusion (RVO). METHODS: Seventy-six patients who presented to the clinic with the diagnosis of RVO and 76 age- and gender-matched he...

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Autores principales: Bozkurt, Erdinc, Cetin, Turkhun, Rencuzogullari, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169147/
https://www.ncbi.nlm.nih.gov/pubmed/35692265
http://dx.doi.org/10.14744/bej.2022.44265
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author Bozkurt, Erdinc
Cetin, Turkhun
Rencuzogullari, Ibrahim
author_facet Bozkurt, Erdinc
Cetin, Turkhun
Rencuzogullari, Ibrahim
author_sort Bozkurt, Erdinc
collection PubMed
description OBJECTIVES: Our aim in this study was to evaluate the systemic endothelial dysfunction status and carotid intima-media thickness (CIMT) in patients with retinal vein occlusion (RVO). METHODS: Seventy-six patients who presented to the clinic with the diagnosis of RVO and 76 age- and gender-matched healthy individuals without a RVO history were included in the study. The patients’ best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measures, and diabetes, hypertension, hyperlipidemia, carotid artery disease, body mass index, and smoking histories were recorded. The endothelial function levels of the patients, pulse wave velocity (PWV), flow-mediated dilation (FMD), and CIMT were measured. Endothelial dysfunction was detected by applying the FMD technique to the brachial artery. CIMT was evaluated by B-mode ultrasonography. Serum hematological parameters were evaluated. RESULTS: BCVA (logMAR) was 1.39±1.30 in patients with RVO and 0.028±1.22 in the control group (p<0.001). CMT was 588.76±104.02 µm in patients with RVO and 265.20±45.11 µm in the control group (p=0.001). Hypertension, diabetes, and hyperlipidemia were found to be significantly higher in patients with RVO (p-value 0.001, 0.002, and 0.001, respectively). There was a significant difference between the groups in terms of FMD, PWV, and CIMT (all of them, p<0.001). CONCLUSION: The deterioration of FMD and PWV, which are indicators of endothelial dysfunction in patients with RVO, suggests that systemic endothelial dysfunction may play a role in the pathogenesis of RVO. Comprehensive studies with more patient participation are needed.
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spelling pubmed-91691472022-06-09 Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions Bozkurt, Erdinc Cetin, Turkhun Rencuzogullari, Ibrahim Beyoglu Eye J Original Article OBJECTIVES: Our aim in this study was to evaluate the systemic endothelial dysfunction status and carotid intima-media thickness (CIMT) in patients with retinal vein occlusion (RVO). METHODS: Seventy-six patients who presented to the clinic with the diagnosis of RVO and 76 age- and gender-matched healthy individuals without a RVO history were included in the study. The patients’ best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measures, and diabetes, hypertension, hyperlipidemia, carotid artery disease, body mass index, and smoking histories were recorded. The endothelial function levels of the patients, pulse wave velocity (PWV), flow-mediated dilation (FMD), and CIMT were measured. Endothelial dysfunction was detected by applying the FMD technique to the brachial artery. CIMT was evaluated by B-mode ultrasonography. Serum hematological parameters were evaluated. RESULTS: BCVA (logMAR) was 1.39±1.30 in patients with RVO and 0.028±1.22 in the control group (p<0.001). CMT was 588.76±104.02 µm in patients with RVO and 265.20±45.11 µm in the control group (p=0.001). Hypertension, diabetes, and hyperlipidemia were found to be significantly higher in patients with RVO (p-value 0.001, 0.002, and 0.001, respectively). There was a significant difference between the groups in terms of FMD, PWV, and CIMT (all of them, p<0.001). CONCLUSION: The deterioration of FMD and PWV, which are indicators of endothelial dysfunction in patients with RVO, suggests that systemic endothelial dysfunction may play a role in the pathogenesis of RVO. Comprehensive studies with more patient participation are needed. Kare Publishing 2022-05-27 /pmc/articles/PMC9169147/ /pubmed/35692265 http://dx.doi.org/10.14744/bej.2022.44265 Text en Copyright: © 2022 by Beyoglu Eye Training and Research Hospital https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Article
Bozkurt, Erdinc
Cetin, Turkhun
Rencuzogullari, Ibrahim
Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions
title Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions
title_full Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions
title_fullStr Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions
title_full_unstemmed Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions
title_short Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions
title_sort evaluation of systemic endothelial dysfunction in retinal vein occlusions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169147/
https://www.ncbi.nlm.nih.gov/pubmed/35692265
http://dx.doi.org/10.14744/bej.2022.44265
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