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Current update on theranostic roles of cyclophilin A in kidney diseases
Cyclophilin A (CyPA) or peptidylprolyl isomerase A (PPIA), an immunophilin with peptidyl-prolyl cis/trans isomerase (PPIase) activity, is an abundant cellular protein widely expressed across various cell types and tissues, including the kidney. Expression of CyPA in the kidney is relatively higher i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169364/ https://www.ncbi.nlm.nih.gov/pubmed/35673572 http://dx.doi.org/10.7150/thno.72948 |
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author | Hadpech, Sudarat Thongboonkerd, Visith |
author_facet | Hadpech, Sudarat Thongboonkerd, Visith |
author_sort | Hadpech, Sudarat |
collection | PubMed |
description | Cyclophilin A (CyPA) or peptidylprolyl isomerase A (PPIA), an immunophilin with peptidyl-prolyl cis/trans isomerase (PPIase) activity, is an abundant cellular protein widely expressed across various cell types and tissues, including the kidney. Expression of CyPA in the kidney is relatively higher in proximal tubular epithelial cells than others along the nephron. Alterations in expression and secretion of CyPA play important roles in physiological processes and pathophysiology of several diseases affecting the kidney. Herein, we provide a brief overview of CyPA structural biology and present the current update on its theranostic roles in various kidney diseases, including diabetic nephropathy, acute kidney injury, chronic kidney disease, renal fibrosis, and nephrotoxicity associated with organ transplantation. Notably, the diagnostic/prognostic role for urinary CyPA in several of these kidney diseases is promising. Finally, future perspectives on the CyPA research, especially targeting CyPA for therapeutics, are discussed. A comprehensive understanding of the theranostic roles of CyPA in kidney diseases is expected to provide novel insights into the design of new therapeutic interventions and prevention strategies. |
format | Online Article Text |
id | pubmed-9169364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-91693642022-06-06 Current update on theranostic roles of cyclophilin A in kidney diseases Hadpech, Sudarat Thongboonkerd, Visith Theranostics Review Cyclophilin A (CyPA) or peptidylprolyl isomerase A (PPIA), an immunophilin with peptidyl-prolyl cis/trans isomerase (PPIase) activity, is an abundant cellular protein widely expressed across various cell types and tissues, including the kidney. Expression of CyPA in the kidney is relatively higher in proximal tubular epithelial cells than others along the nephron. Alterations in expression and secretion of CyPA play important roles in physiological processes and pathophysiology of several diseases affecting the kidney. Herein, we provide a brief overview of CyPA structural biology and present the current update on its theranostic roles in various kidney diseases, including diabetic nephropathy, acute kidney injury, chronic kidney disease, renal fibrosis, and nephrotoxicity associated with organ transplantation. Notably, the diagnostic/prognostic role for urinary CyPA in several of these kidney diseases is promising. Finally, future perspectives on the CyPA research, especially targeting CyPA for therapeutics, are discussed. A comprehensive understanding of the theranostic roles of CyPA in kidney diseases is expected to provide novel insights into the design of new therapeutic interventions and prevention strategies. Ivyspring International Publisher 2022-05-13 /pmc/articles/PMC9169364/ /pubmed/35673572 http://dx.doi.org/10.7150/thno.72948 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Hadpech, Sudarat Thongboonkerd, Visith Current update on theranostic roles of cyclophilin A in kidney diseases |
title | Current update on theranostic roles of cyclophilin A in kidney diseases |
title_full | Current update on theranostic roles of cyclophilin A in kidney diseases |
title_fullStr | Current update on theranostic roles of cyclophilin A in kidney diseases |
title_full_unstemmed | Current update on theranostic roles of cyclophilin A in kidney diseases |
title_short | Current update on theranostic roles of cyclophilin A in kidney diseases |
title_sort | current update on theranostic roles of cyclophilin a in kidney diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169364/ https://www.ncbi.nlm.nih.gov/pubmed/35673572 http://dx.doi.org/10.7150/thno.72948 |
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