Recent advances in understanding the role of HES6 in cancers

The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key...

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Detalles Bibliográficos
Autores principales: Krossa, Imène, Strub, Thomas, Martel, Arnaud, Nahon-Esteve, Sacha, Lassalle, Sandra, Hofman, Paul, Baillif, Stéphanie, Ballotti, Robert, Bertolotto, Corine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169368/
https://www.ncbi.nlm.nih.gov/pubmed/35673577
http://dx.doi.org/10.7150/thno.72966
Descripción
Sumario:The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.

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