Recent advances in understanding the role of HES6 in cancers

The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key...

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Autores principales: Krossa, Imène, Strub, Thomas, Martel, Arnaud, Nahon-Esteve, Sacha, Lassalle, Sandra, Hofman, Paul, Baillif, Stéphanie, Ballotti, Robert, Bertolotto, Corine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169368/
https://www.ncbi.nlm.nih.gov/pubmed/35673577
http://dx.doi.org/10.7150/thno.72966
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author Krossa, Imène
Strub, Thomas
Martel, Arnaud
Nahon-Esteve, Sacha
Lassalle, Sandra
Hofman, Paul
Baillif, Stéphanie
Ballotti, Robert
Bertolotto, Corine
author_facet Krossa, Imène
Strub, Thomas
Martel, Arnaud
Nahon-Esteve, Sacha
Lassalle, Sandra
Hofman, Paul
Baillif, Stéphanie
Ballotti, Robert
Bertolotto, Corine
author_sort Krossa, Imène
collection PubMed
description The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.
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spelling pubmed-91693682022-06-06 Recent advances in understanding the role of HES6 in cancers Krossa, Imène Strub, Thomas Martel, Arnaud Nahon-Esteve, Sacha Lassalle, Sandra Hofman, Paul Baillif, Stéphanie Ballotti, Robert Bertolotto, Corine Theranostics Review The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers. Ivyspring International Publisher 2022-05-20 /pmc/articles/PMC9169368/ /pubmed/35673577 http://dx.doi.org/10.7150/thno.72966 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Krossa, Imène
Strub, Thomas
Martel, Arnaud
Nahon-Esteve, Sacha
Lassalle, Sandra
Hofman, Paul
Baillif, Stéphanie
Ballotti, Robert
Bertolotto, Corine
Recent advances in understanding the role of HES6 in cancers
title Recent advances in understanding the role of HES6 in cancers
title_full Recent advances in understanding the role of HES6 in cancers
title_fullStr Recent advances in understanding the role of HES6 in cancers
title_full_unstemmed Recent advances in understanding the role of HES6 in cancers
title_short Recent advances in understanding the role of HES6 in cancers
title_sort recent advances in understanding the role of hes6 in cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169368/
https://www.ncbi.nlm.nih.gov/pubmed/35673577
http://dx.doi.org/10.7150/thno.72966
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