First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome

Different human races across the globe responded in a different way to the SARS-CoV-2 infection leading to different disease severity. Therefore, it is anticipated that host genetic factors have a straight association with the COVID-19. We identified a total 6, 7, and 6 genomic loci for deceased-rec...

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Detalles Bibliográficos
Autores principales: Pandit, Ramesh, Singh, Indra, Ansari, Afzal, Raval, Janvi, Patel, Zarna, Dixit, Raghav, Shah, Pranay, Upadhyay, Kamlesh, Chauhan, Naresh, Desai, Kairavi, Shah, Meenakshi, Modi, Bhavesh, Joshi, Madhvi, Joshi, Chaitanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169419/
https://www.ncbi.nlm.nih.gov/pubmed/35680011
http://dx.doi.org/10.1016/j.ygeno.2022.110399
Descripción
Sumario:Different human races across the globe responded in a different way to the SARS-CoV-2 infection leading to different disease severity. Therefore, it is anticipated that host genetic factors have a straight association with the COVID-19. We identified a total 6, 7, and 6 genomic loci for deceased-recovered, asymptomatic-recovered, and deceased-asymptomatic group comparison, respectively. Unfavourable alleles of the markers nearby the genes which are associated with lung and heart diseases such as Tumor necrosis factor superfamily (TNFSF4&18), showed noteworthy association with the disease severity and outcome for the COVID-19 patients in the western Indian population. The markers found with significant association with disease prognosis or recovery are of value in determining the individual's response to SARS-CoV-2 infection and can be used for the risk prediction in COVID-19. Besides, GWAS study in other populations from India may help to strengthen the outcome of this study.

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