First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome

Different human races across the globe responded in a different way to the SARS-CoV-2 infection leading to different disease severity. Therefore, it is anticipated that host genetic factors have a straight association with the COVID-19. We identified a total 6, 7, and 6 genomic loci for deceased-rec...

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Autores principales: Pandit, Ramesh, Singh, Indra, Ansari, Afzal, Raval, Janvi, Patel, Zarna, Dixit, Raghav, Shah, Pranay, Upadhyay, Kamlesh, Chauhan, Naresh, Desai, Kairavi, Shah, Meenakshi, Modi, Bhavesh, Joshi, Madhvi, Joshi, Chaitanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169419/
https://www.ncbi.nlm.nih.gov/pubmed/35680011
http://dx.doi.org/10.1016/j.ygeno.2022.110399
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author Pandit, Ramesh
Singh, Indra
Ansari, Afzal
Raval, Janvi
Patel, Zarna
Dixit, Raghav
Shah, Pranay
Upadhyay, Kamlesh
Chauhan, Naresh
Desai, Kairavi
Shah, Meenakshi
Modi, Bhavesh
Joshi, Madhvi
Joshi, Chaitanya
author_facet Pandit, Ramesh
Singh, Indra
Ansari, Afzal
Raval, Janvi
Patel, Zarna
Dixit, Raghav
Shah, Pranay
Upadhyay, Kamlesh
Chauhan, Naresh
Desai, Kairavi
Shah, Meenakshi
Modi, Bhavesh
Joshi, Madhvi
Joshi, Chaitanya
author_sort Pandit, Ramesh
collection PubMed
description Different human races across the globe responded in a different way to the SARS-CoV-2 infection leading to different disease severity. Therefore, it is anticipated that host genetic factors have a straight association with the COVID-19. We identified a total 6, 7, and 6 genomic loci for deceased-recovered, asymptomatic-recovered, and deceased-asymptomatic group comparison, respectively. Unfavourable alleles of the markers nearby the genes which are associated with lung and heart diseases such as Tumor necrosis factor superfamily (TNFSF4&18), showed noteworthy association with the disease severity and outcome for the COVID-19 patients in the western Indian population. The markers found with significant association with disease prognosis or recovery are of value in determining the individual's response to SARS-CoV-2 infection and can be used for the risk prediction in COVID-19. Besides, GWAS study in other populations from India may help to strengthen the outcome of this study.
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spelling pubmed-91694192022-06-07 First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome Pandit, Ramesh Singh, Indra Ansari, Afzal Raval, Janvi Patel, Zarna Dixit, Raghav Shah, Pranay Upadhyay, Kamlesh Chauhan, Naresh Desai, Kairavi Shah, Meenakshi Modi, Bhavesh Joshi, Madhvi Joshi, Chaitanya Genomics Article Different human races across the globe responded in a different way to the SARS-CoV-2 infection leading to different disease severity. Therefore, it is anticipated that host genetic factors have a straight association with the COVID-19. We identified a total 6, 7, and 6 genomic loci for deceased-recovered, asymptomatic-recovered, and deceased-asymptomatic group comparison, respectively. Unfavourable alleles of the markers nearby the genes which are associated with lung and heart diseases such as Tumor necrosis factor superfamily (TNFSF4&18), showed noteworthy association with the disease severity and outcome for the COVID-19 patients in the western Indian population. The markers found with significant association with disease prognosis or recovery are of value in determining the individual's response to SARS-CoV-2 infection and can be used for the risk prediction in COVID-19. Besides, GWAS study in other populations from India may help to strengthen the outcome of this study. The Authors. Published by Elsevier Inc. 2022-07 2022-06-06 /pmc/articles/PMC9169419/ /pubmed/35680011 http://dx.doi.org/10.1016/j.ygeno.2022.110399 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pandit, Ramesh
Singh, Indra
Ansari, Afzal
Raval, Janvi
Patel, Zarna
Dixit, Raghav
Shah, Pranay
Upadhyay, Kamlesh
Chauhan, Naresh
Desai, Kairavi
Shah, Meenakshi
Modi, Bhavesh
Joshi, Madhvi
Joshi, Chaitanya
First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome
title First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome
title_full First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome
title_fullStr First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome
title_full_unstemmed First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome
title_short First report on genome wide association study in western Indian population reveals host genetic factors for COVID-19 severity and outcome
title_sort first report on genome wide association study in western indian population reveals host genetic factors for covid-19 severity and outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169419/
https://www.ncbi.nlm.nih.gov/pubmed/35680011
http://dx.doi.org/10.1016/j.ygeno.2022.110399
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