Cargando…

Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus

In the search for structurally novel metabolites with antibacterial activity, innovative approaches must be implemented to increase the probability of discovering novel chemistry from microbial sources. Here we report on the application of metabolomic tools to the genus Actinoallomurus, a poorly exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iorio, Marianna, Gentile, Andrea, Brunati, Cristina, Tocchetti, Arianna, Landini, Paolo, Maffioli, Sonia Ilaria, Donadio, Stefano, Sosio, Margherita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169493/ https://www.ncbi.nlm.nih.gov/pubmed/35754877 http://dx.doi.org/10.1039/d2ra02094g

Ejemplares similares

Novel Polyethers from Screening Actinoallomurus spp.
por: Iorio, Marianna, et al.
Publicado: (2018)

Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
por: Theobald, Sebastian, et al.
Publicado: (2019)

Antimicrobial potential of Actinomycetes by NRPS and PKS-I pathways
por: Hernández- Macedo, Maria Lucila, et al.
Publicado: (2014)

Effective approaches to discover new microbial metabolites in a large strain library
por: Zdouc, Mitja M, et al.
Publicado: (2021)

ClusterMine360: a database of microbial PKS/NRPS biosynthesis
por: Conway, Kyle R., et al.
Publicado: (2013)

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
por: Awakawa, Takayoshi, et al.
Publicado: (2018)

Identification of PKS-NRPS Hybrid Metabolites in Marine-Derived Penicillium oxalicum
por: Li, Hongcheng, et al.
Publicado: (2022)

A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin
por: Zhang, Hongjiao, et al.
Publicado: (2022)

Discovering new bioactive molecules from microbial sources
por: Monciardini, Paolo, et al.
Publicado: (2014)

Megalochelin, a Tridecapeptide Siderophore from a Talented Streptomycete
por: Vind, Kristiina, et al.
Publicado: (2023)

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme
por: Yun, Choong-Soo, et al.
Publicado: (2015)

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering
por: Nielsen, Maria Lund, et al.
Publicado: (2016)

Bioactive PKS–NRPS Alkaloids from the Plant-Derived Endophytic Fungus Xylaria arbuscula
por: Wang, Ya, et al.
Publicado: (2021)

Epilithic Biofilms in Lake Baikal: Screening and Diversity of PKS and NRPS Genes in the Genomes of Heterotrophic Bacteria
por: SUKHANOVA, ELENA, et al.
Publicado: (2018)

Variations of Indole Metabolites and NRPS-PKS Loci in Two Different Virulent Strains of Xenorhabdus hominickii
por: Mollah, Md. Mahi Imam, et al.
Publicado: (2020)

Taxogenomic and Comparative Genomic Analysis of the Genus Saccharomonospora Focused on the Identification of Biosynthetic Clusters PKS and NRPS
por: Ramírez-Durán, Ninfa, et al.
Publicado: (2021)

Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian
por: Avalon, Nicole E., et al.
Publicado: (2021)

Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus
por: Zdouc, Mitja M., et al.
Publicado: (2021)

Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells
por: Brunati, Cristina, et al.
Publicado: (2018)

N-Acetyl-Cysteinylated Streptophenazines from Streptomyces
por: Vind, Kristiina, et al.
Publicado: (2022)

Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils
por: Amos, Gregory C. A., et al.
Publicado: (2015)

Characterization of NRPS and PKS genes involved in the biosynthesis of SMs in Alternaria dauci including the phytotoxic polyketide aldaulactone
por: Courtial, Julia, et al.
Publicado: (2022)

Optimization of Degenerate PCR Conditions for Reducing Error Rates in Detection of PKS and NRPS Gene groups in Actinomycetes
por: Ghashghaei, Sara, et al.
Publicado: (2023)

Genome Mining Uncovers NRPS and PKS Clusters in Rothia dentocariosa with Inhibitory Activity against Neisseria Species
por: Akomoneh, Elvis Achondou, et al.
Publicado: (2023)

A Hybrid NRPS-PKS Gene Cluster Related to the Bleomycin Family of Antitumor Antibiotics in Alteromonas macleodii Strains
por: Mizuno, Carolina Megumi, et al.
Publicado: (2013)

Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata
por: Zhang, Chen, et al.
Publicado: (2017)

The Mosaic Architecture of NRPS-PKS in the Arbuscular Mycorrhizal Fungus Gigaspora margarita Shows a Domain With Bacterial Signature
por: Venice, Francesco, et al.
Publicado: (2020)

In Silico Analysis of PKS and NRPS Gene Clusters in Arisostatin- and Kosinostatin-Producers and Description of Micromonospora okii sp. nov.
por: Komaki, Hisayuki, et al.
Publicado: (2021)

A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance
por: Alduina, Rosa, et al.
Publicado: (2020)

Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products
por: Dhaneesha, M., et al.
Publicado: (2017)

Classification of the Adenylation and Acyl-Transferase Activity of NRPS and PKS Systems Using Ensembles of Substrate Specific Hidden Markov Models
por: Khayatt, Barzan I., et al.
Publicado: (2013)

Metagenomic Analysis of Upwelling-Affected Brazilian Coastal Seawater Reveals Sequence Domains of Type I PKS and Modular NRPS
por: Cuadrat, Rafael R. C., et al.
Publicado: (2015)

Isolation and Biosynthetic Analysis of Haliamide, a New PKS-NRPS Hybrid Metabolite from the Marine Myxobacterium Haliangium ochraceum
por: Sun, Yuwei, et al.
Publicado: (2016)

Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii
por: Bertin, Matthew J., et al.
Publicado: (2017)

SeMPI 2.0—A Web Server for PKS and NRPS Predictions Combined with Metabolite Screening in Natural Product Databases
por: Zierep, Paul F., et al.
Publicado: (2020)

Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996
por: Zhang, Tao, et al.
Publicado: (2022)

Understanding the Mechanism of Action of NAI-112, a Lanthipeptide with Potent Antinociceptive Activity
por: Tocchetti, Arianna, et al.
Publicado: (2021)

Full-length title: NRPPUR database search and in vitro analysis identify an NRPS-PKS biosynthetic gene cluster with a potential antibiotic effect
por: Fritz, Shirley, et al.
Publicado: (2018)

Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain
por: Iorio, Marianna, et al.
Publicado: (2021)

A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877
por: Bunet, Robert, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9kqc6q1uocp4thcfnrslc35kt7