Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

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The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA vaccine candidate, and test its activity in animals, both alone and as a heterologous booster to WT mRNA vaccine. Our Omicron-specif...

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Detalles Bibliográficos
Autores principales: Fang, Zhenhao, Peng, Lei, Filler, Renata, Suzuki, Kazushi, McNamara, Andrew, Lin, Qianqian, Renauer, Paul A., Yang, Luojia, Menasche, Bridget, Sanchez, Angie, Ren, Ping, Xiong, Qiancheng, Strine, Madison, Clark, Paul, Lin, Chenxiang, Ko, Albert I., Grubaugh, Nathan D., Wilen, Craig B., Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169595/
https://www.ncbi.nlm.nih.gov/pubmed/35668119
http://dx.doi.org/10.1038/s41467-022-30878-4
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