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Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B

Conventional treatment of chronic hepatitis B (CHB) is rarely curative due to the immunotolerant status of patients. RG7854 is an oral double prodrug of a toll-like receptor 7 (TLR7) agonist that is developed for the treatment of CHB. The therapeutic efficacy, host immune response, and safety of RG7...

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Detalles Bibliográficos
Autores principales:	Wildum, Steffen, Korolowicz, Kyle E., Suresh, Manasa, Steiner, Guido, Dai, Lue, Li, Bin, Yon, Changsuek, De Vera Mudry, Maria Cristina, Regenass-Lechner, Franziska, Huang, Xu, Hong, Xupeng, Murreddu, Marta G., Kallakury, Bhaskar V., Young, John A. T., Menne, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169629/ https://www.ncbi.nlm.nih.gov/pubmed/35677037 http://dx.doi.org/10.3389/fimmu.2022.884113

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