α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, the pathogenic relevance of pS129–α-syn remains controversial, so we sought to identify when pS129 modificat...

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Detalles Bibliográficos
Autores principales: Ghanem, Simona S., Majbour, Nour K., Vaikath, Nishant N., Ardah, Mustafa T., Erskine, Daniel, Jensen, Nanna Møller, Fayyad, Muneera, Sudhakaran, Indulekha P., Vasili, Eftychia, Melachroinou, Katerina, Abdi, Ilham Y., Poggiolini, Ilaria, Santos, Patricia, Dorn, Anton, Carloni, Paolo, Vekrellis, Kostas, Attems, Johannes, McKeith, Ian, Outeiro, Tiago F., Jensen, Poul Henning, El-Agnaf, Omar M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169642/
https://www.ncbi.nlm.nih.gov/pubmed/35353605
http://dx.doi.org/10.1073/pnas.2109617119

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