Cargando…
Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity
In pathological or artificial conditions, memory can be formed as silenced engrams that are unavailable for retrieval by presenting conditioned stimuli but can be artificially switched into the latent state so that natural recall is allowed. However, it remains unclear whether such different states...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169661/ https://www.ncbi.nlm.nih.gov/pubmed/35377811 http://dx.doi.org/10.1073/pnas.2116844119 |
_version_ | 1784721249271808000 |
---|---|
author | Lei, Bo Lv, Li Hu, Shiqiang Tang, Yikai Zhong, Yi |
author_facet | Lei, Bo Lv, Li Hu, Shiqiang Tang, Yikai Zhong, Yi |
author_sort | Lei, Bo |
collection | PubMed |
description | In pathological or artificial conditions, memory can be formed as silenced engrams that are unavailable for retrieval by presenting conditioned stimuli but can be artificially switched into the latent state so that natural recall is allowed. However, it remains unclear whether such different states of engrams bear any physiological significance and can be switched through physiological mechanisms. Here, we show that an acute social reward experience switches the silent memory engram into the latent state. Conversely, an acute social stress causes transient forgetting via turning a latent memory engram into a silent state. Such emotion-driven bidirectional switching between latent and silent states of engrams is mediated through regulation of Rac1 activity–dependent reversible forgetting in the hippocampus, as stress-activated Rac1 suppresses retrieval, while reward recovers silenced memory under amnesia by inhibiting Rac1. Thus, data presented reveal hippocampal Rac1 activity as the basis for emotion-mediated switching between latent and silent engrams to achieve emotion-driven behavioral flexibility. |
format | Online Article Text |
id | pubmed-9169661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-91696612022-06-07 Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity Lei, Bo Lv, Li Hu, Shiqiang Tang, Yikai Zhong, Yi Proc Natl Acad Sci U S A Biological Sciences In pathological or artificial conditions, memory can be formed as silenced engrams that are unavailable for retrieval by presenting conditioned stimuli but can be artificially switched into the latent state so that natural recall is allowed. However, it remains unclear whether such different states of engrams bear any physiological significance and can be switched through physiological mechanisms. Here, we show that an acute social reward experience switches the silent memory engram into the latent state. Conversely, an acute social stress causes transient forgetting via turning a latent memory engram into a silent state. Such emotion-driven bidirectional switching between latent and silent states of engrams is mediated through regulation of Rac1 activity–dependent reversible forgetting in the hippocampus, as stress-activated Rac1 suppresses retrieval, while reward recovers silenced memory under amnesia by inhibiting Rac1. Thus, data presented reveal hippocampal Rac1 activity as the basis for emotion-mediated switching between latent and silent engrams to achieve emotion-driven behavioral flexibility. National Academy of Sciences 2022-04-04 2022-04-12 /pmc/articles/PMC9169661/ /pubmed/35377811 http://dx.doi.org/10.1073/pnas.2116844119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Lei, Bo Lv, Li Hu, Shiqiang Tang, Yikai Zhong, Yi Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity |
title | Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity |
title_full | Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity |
title_fullStr | Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity |
title_full_unstemmed | Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity |
title_short | Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity |
title_sort | social experiences switch states of memory engrams through regulating hippocampal rac1 activity |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169661/ https://www.ncbi.nlm.nih.gov/pubmed/35377811 http://dx.doi.org/10.1073/pnas.2116844119 |
work_keys_str_mv | AT leibo socialexperiencesswitchstatesofmemoryengramsthroughregulatinghippocampalrac1activity AT lvli socialexperiencesswitchstatesofmemoryengramsthroughregulatinghippocampalrac1activity AT hushiqiang socialexperiencesswitchstatesofmemoryengramsthroughregulatinghippocampalrac1activity AT tangyikai socialexperiencesswitchstatesofmemoryengramsthroughregulatinghippocampalrac1activity AT zhongyi socialexperiencesswitchstatesofmemoryengramsthroughregulatinghippocampalrac1activity |