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Activation mechanism of the μ-opioid receptor by an allosteric modulator

Allosteric modulators of G-protein-coupled receptors (GPCRs) enhance signaling by binding to GPCRs concurrently with their orthosteric ligands, offering a novel approach to overcome the efficacy limitations of conventional orthosteric ligands. However, the structural mechanism by which allosteric mo...

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Detalles Bibliográficos
Autores principales:	Kaneko, Shun, Imai, Shunsuke, Asao, Nobuaki, Kofuku, Yutaka, Ueda, Takumi, Shimada, Ichio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169721/ https://www.ncbi.nlm.nih.gov/pubmed/35412886 http://dx.doi.org/10.1073/pnas.2121918119

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