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Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle

Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies due to structural and dynamic changes of the viral spike glycoprotein (S). The heptad repeat 1 (HR1) and heptad repeat 2 (HR2) domains of S drive...

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Detalles Bibliográficos
Autores principales: Yang, Kailu, Wang, Chuchu, White, K. Ian, Pfuetzner, Richard A., Esquivies, Luis, Brunger, Axel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169775/
https://www.ncbi.nlm.nih.gov/pubmed/35363556
http://dx.doi.org/10.1073/pnas.2119467119