Cargando…

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle

Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies due to structural and dynamic changes of the viral spike glycoprotein (S). The heptad repeat 1 (HR1) and heptad repeat 2 (HR2) domains of S drive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Kailu, Wang, Chuchu, White, K. Ian, Pfuetzner, Richard A., Esquivies, Luis, Brunger, Axel T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169775/ https://www.ncbi.nlm.nih.gov/pubmed/35363556 http://dx.doi.org/10.1073/pnas.2119467119

Ejemplares similares

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor
por: Yang, Kailu, et al.
Publicado: (2023)

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
por: Yang, Kailu, et al.
Publicado: (2022)

Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein
por: Tai, Linhua, et al.
Publicado: (2021)

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
por: Choi, Ucheor B, et al.
Publicado: (2018)

The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET
por: Liu, Chuang, et al.
Publicado: (2020)

Drug discovery targeting SARS-CoV-2 membrane fusion
por: Yang, Kailu, et al.
Publicado: (2023)

SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis
por: McGrath, Marisa E., et al.
Publicado: (2022)

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
por: Jaczynska, Klaudia, et al.
Publicado: (2022)

Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
por: Lai, Ying, et al.
Publicado: (2022)

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
por: Lai, Ying, et al.
Publicado: (2023)

Pre-and Postfusion Tuning of Regulated Exocytosis by Cell Metabolites
por: Zorec, Robert, et al.
Publicado: (2022)

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021)

Targeting spike glycans to inhibit SARS-CoV2 viral entry
por: Guseman, Alex J., et al.
Publicado: (2023)

SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern
por: Lu, Mijia, et al.
Publicado: (2022)

Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein
por: Dean, Trevor T., et al.
Publicado: (2022)

Distant residues modulate conformational opening in SARS-CoV-2 spike protein
por: Ray, Dhiman, et al.
Publicado: (2021)

Structural principles of SNARE complex recognition by the AAA+ protein NSF
por: White, K Ian, et al.
Publicado: (2018)

Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2
por: Muñoz-Basagoiti, Jordana, et al.
Publicado: (2023)

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2
por: Xiong, Hualong, et al.
Publicado: (2022)

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2
por: Benton, Donald J., et al.
Publicado: (2021)

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike
por: Mehdipour, Ahmad Reza, et al.
Publicado: (2021)

Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
por: Lai, Ying, et al.
Publicado: (2022)

Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms
por: Lai, Ying, et al.
Publicado: (2014)

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation
por: Más, Vicente, et al.
Publicado: (2016)

Interferon resistance of emerging SARS-CoV-2 variants
por: Guo, Kejun, et al.
Publicado: (2022)

Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine
por: Wu, Chung-Yi, et al.
Publicado: (2022)

SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation
por: Yu, Shi, et al.
Publicado: (2021)

Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective interaction with host cell receptors
por: Kapoor, Karan, et al.
Publicado: (2022)

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes
por: Mikolajek, Halina, et al.
Publicado: (2022)

A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike
por: Lu, Mijia, et al.
Publicado: (2021)

Generation of monoclonal antibodies specific of the postfusion conformation of the Pneumovirinae fusion (F) protein
por: Rodríguez, Laura, et al.
Publicado: (2015)

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
por: Guenthoer, Jamie, et al.
Publicado: (2023)

Characterization of a new SARS-CoV-2 variant that emerged in Brazil
por: Imai, Masaki, et al.
Publicado: (2021)

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants
por: Hong, Jessica, et al.
Publicado: (2022)

In situ architecture and membrane fusion of SARS-CoV-2 Delta variant
por: Song, Yutong, et al.
Publicado: (2023)

SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection
por: Bashor, Laura, et al.
Publicado: (2021)

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant
por: Zhang, Wei, et al.
Publicado: (2022)

An intramolecular salt bridge drives the soluble domain of GTP-bound atlastin into the postfusion conformation
por: Morin-Leisk, Jeanne, et al.
Publicado: (2011)

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody
por: Chandramouli, Sumana, et al.
Publicado: (2015)

Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state
por: Feng, Juan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9u10880jsib2kf089e8l64olas