A molecular complex of Ca(v)1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation–transcription coupling

Elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)) activates Ca(2+)/calmodulin-dependent kinases (CaMK) and promotes gene transcription. This signaling pathway is referred to as excitation–transcription (E-T) coupling. Although vascular myocytes can exhibit E-T coupling, the molecular mec...

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Detalles Bibliográficos
Autores principales: Suzuki, Yoshiaki, Ozawa, Takumi, Kurata, Tomo, Nakajima, Nanami, Zamponi, Gerald W., Giles, Wayne R., Imaizumi, Yuji, Yamamura, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169798/
https://www.ncbi.nlm.nih.gov/pubmed/35412911
http://dx.doi.org/10.1073/pnas.2117435119

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