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An extended conformation of SARS-CoV-2 main protease reveals allosteric targets

The coronavirus main protease (M(pro)) is required for viral replication and has enzymatical activity as a homodimer. Thus, targeting its dimerization is an effective strategy for developing allosteric inhibitors to suppress mutation escape. In this study, we obtained the extended conformation of th...

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Detalles Bibliográficos
Autores principales:	Sun, Zengchao, Wang, Lu, Li, Xiyang, Fan, Chengpeng, Xu, Jianfeng, Shi, Zhenzhong, Qiao, Huarui, Lan, Zhongyun, Zhang, Xin, Li, Lingyun, Zhou, Xin, Geng, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169858/ https://www.ncbi.nlm.nih.gov/pubmed/35324337 http://dx.doi.org/10.1073/pnas.2120913119

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