Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments

The glucocorticoid receptor (GR) is an important transcription factor and drug target linked to a variety of biological functions and diseases. It is one of the most stringent physiological clients of the Hsp90/Hsp70/Hsp40 chaperone system. In this study, we used single-molecule force spectroscopy b...

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Detalles Bibliográficos
Autores principales: Moessmer, Patrick, Suren, Thomas, Majdic, Ulrike, Dahiya, Vinay, Rutz, Daniel, Buchner, Johannes, Rief, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169861/
https://www.ncbi.nlm.nih.gov/pubmed/35377810
http://dx.doi.org/10.1073/pnas.2119076119

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