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Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study

OBJECTIVES: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood. METHODS: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were in...

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Autores principales: Lee, Hye Jin, Lim, Youn-Hee, Hong, Yun-Chul, Shin, Choong Ho, Lee, Young Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169890/
https://www.ncbi.nlm.nih.gov/pubmed/35677718
http://dx.doi.org/10.3389/fendo.2022.872591
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author Lee, Hye Jin
Lim, Youn-Hee
Hong, Yun-Chul
Shin, Choong Ho
Lee, Young Ah
author_facet Lee, Hye Jin
Lim, Youn-Hee
Hong, Yun-Chul
Shin, Choong Ho
Lee, Young Ah
author_sort Lee, Hye Jin
collection PubMed
description OBJECTIVES: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood. METHODS: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2–3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4. RESULTS: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2–3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2–3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2–3 at age 4 did not affect glucose or IR at 4 years. CONCLUSION: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.
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spelling pubmed-91698902022-06-07 Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study Lee, Hye Jin Lim, Youn-Hee Hong, Yun-Chul Shin, Choong Ho Lee, Young Ah Front Endocrinol (Lausanne) Endocrinology OBJECTIVES: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood. METHODS: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2–3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4. RESULTS: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2–3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2–3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2–3 at age 4 did not affect glucose or IR at 4 years. CONCLUSION: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9169890/ /pubmed/35677718 http://dx.doi.org/10.3389/fendo.2022.872591 Text en Copyright © 2022 Lee, Lim, Hong, Shin and Lee https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lee, Hye Jin
Lim, Youn-Hee
Hong, Yun-Chul
Shin, Choong Ho
Lee, Young Ah
Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
title Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
title_full Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
title_fullStr Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
title_full_unstemmed Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
title_short Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
title_sort body mass index changes and insulin resistance at age 4: a prospective cohort study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169890/
https://www.ncbi.nlm.nih.gov/pubmed/35677718
http://dx.doi.org/10.3389/fendo.2022.872591
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