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In silico exploration of amyloid‐related imaging abnormalities in the gantenerumab open‐label extension trials using a semi‐mechanistic model

INTRODUCTION: Amyloid‐related imaging abnormalities with edema/effusion (ARIA‐E) are commonly observed with anti‐amyloid therapies in Alzheimer's disease. We developed a semi‐mechanistic, in silico model to understand the time course of ARIA‐E and its dose dependency. METHODS: Dynamic and stati...

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Detalles Bibliográficos
Autores principales:	Aldea, Roxana, Grimm, Hans Peter, Gieschke, Ronald, Hofmann, Carsten, Lott, Dominik, Bullain, Szofia, Delmar, Paul, Klein, Gregory, Lyons, Marco, Piazza, Fabrizio, Carare, Roxana O., Mazer, Norman A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169977/ https://www.ncbi.nlm.nih.gov/pubmed/35676943 http://dx.doi.org/10.1002/trc2.12306

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