Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient

Epstein-Barr virus (EBV)-associated smooth muscle tumors (SMT) have been described in immunosuppressed states, including in post-transplant patients. Here, we discuss a heart-liver transplant recipient who was found to have multifocal hepatic EBV-SMT. His immunosuppression was initially transitioned...

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Autores principales: Johnson, Brett M., Iskandar, Jean-Pierre, Farha, Natalie, Yerian, Lisa, Modaresi Esfeh, Jamak, Lindenmeyer, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169994/
https://www.ncbi.nlm.nih.gov/pubmed/35677812
http://dx.doi.org/10.14309/crj.0000000000000782
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author Johnson, Brett M.
Iskandar, Jean-Pierre
Farha, Natalie
Yerian, Lisa
Modaresi Esfeh, Jamak
Lindenmeyer, Christina
author_facet Johnson, Brett M.
Iskandar, Jean-Pierre
Farha, Natalie
Yerian, Lisa
Modaresi Esfeh, Jamak
Lindenmeyer, Christina
author_sort Johnson, Brett M.
collection PubMed
description Epstein-Barr virus (EBV)-associated smooth muscle tumors (SMT) have been described in immunosuppressed states, including in post-transplant patients. Here, we discuss a heart-liver transplant recipient who was found to have multifocal hepatic EBV-SMT. His immunosuppression was initially transitioned from tacrolimus to sirolimus because of the proposed benefits of the mechanistic target of rapamycin inhibitors on EBV-SMT. Unfortunately, he suffered acute rejection of his liver allograft while on sirolimus therapy, which ultimately led to consideration of retransplantation.
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spelling pubmed-91699942022-06-07 Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient Johnson, Brett M. Iskandar, Jean-Pierre Farha, Natalie Yerian, Lisa Modaresi Esfeh, Jamak Lindenmeyer, Christina ACG Case Rep J Case Report Epstein-Barr virus (EBV)-associated smooth muscle tumors (SMT) have been described in immunosuppressed states, including in post-transplant patients. Here, we discuss a heart-liver transplant recipient who was found to have multifocal hepatic EBV-SMT. His immunosuppression was initially transitioned from tacrolimus to sirolimus because of the proposed benefits of the mechanistic target of rapamycin inhibitors on EBV-SMT. Unfortunately, he suffered acute rejection of his liver allograft while on sirolimus therapy, which ultimately led to consideration of retransplantation. Wolters Kluwer 2022-06-06 /pmc/articles/PMC9169994/ /pubmed/35677812 http://dx.doi.org/10.14309/crj.0000000000000782 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Johnson, Brett M.
Iskandar, Jean-Pierre
Farha, Natalie
Yerian, Lisa
Modaresi Esfeh, Jamak
Lindenmeyer, Christina
Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient
title Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient
title_full Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient
title_fullStr Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient
title_full_unstemmed Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient
title_short Hepatic Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Heart and Liver Transplant Recipient
title_sort hepatic epstein-barr virus-associated smooth muscle tumor in a heart and liver transplant recipient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169994/
https://www.ncbi.nlm.nih.gov/pubmed/35677812
http://dx.doi.org/10.14309/crj.0000000000000782
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