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Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes

B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show that in contrast to the canonical view that G1 progression signals are essential after mitosis to reenter S phase, B lymphocytes sustain sev...

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Autores principales: Singh, Amit, Spitzer, Matthew H., Joy, Jaimy P., Kaileh, Mary, Qiu, Xiang, Nolan, Garry P., Sen, Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170024/
https://www.ncbi.nlm.nih.gov/pubmed/35476510
http://dx.doi.org/10.1073/pnas.2115567119
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author Singh, Amit
Spitzer, Matthew H.
Joy, Jaimy P.
Kaileh, Mary
Qiu, Xiang
Nolan, Garry P.
Sen, Ranjan
author_facet Singh, Amit
Spitzer, Matthew H.
Joy, Jaimy P.
Kaileh, Mary
Qiu, Xiang
Nolan, Garry P.
Sen, Ranjan
author_sort Singh, Amit
collection PubMed
description B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show that in contrast to the canonical view that G1 progression signals are essential after mitosis to reenter S phase, B lymphocytes sustain several rounds of mitogen-independent cell division following the first mitosis. Such division appears to be driven by unique characteristics of the postmitotic G1 phase that has features of S and G2/M phases. Birc5 (survivin), a protein associated with chromosome segregation in G2/M, is expressed in the G1 phase of divided B cells and is necessary for mitogen-independent divisions. The partially active G1 phase and propensity for apoptosis inherited after each division may underlie rapid proliferation and cell death, which are hallmarks of B cell proliferative responses.
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spelling pubmed-91700242022-06-07 Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes Singh, Amit Spitzer, Matthew H. Joy, Jaimy P. Kaileh, Mary Qiu, Xiang Nolan, Garry P. Sen, Ranjan Proc Natl Acad Sci U S A Biological Sciences B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show that in contrast to the canonical view that G1 progression signals are essential after mitosis to reenter S phase, B lymphocytes sustain several rounds of mitogen-independent cell division following the first mitosis. Such division appears to be driven by unique characteristics of the postmitotic G1 phase that has features of S and G2/M phases. Birc5 (survivin), a protein associated with chromosome segregation in G2/M, is expressed in the G1 phase of divided B cells and is necessary for mitogen-independent divisions. The partially active G1 phase and propensity for apoptosis inherited after each division may underlie rapid proliferation and cell death, which are hallmarks of B cell proliferative responses. National Academy of Sciences 2022-04-27 2022-05-03 /pmc/articles/PMC9170024/ /pubmed/35476510 http://dx.doi.org/10.1073/pnas.2115567119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Singh, Amit
Spitzer, Matthew H.
Joy, Jaimy P.
Kaileh, Mary
Qiu, Xiang
Nolan, Garry P.
Sen, Ranjan
Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
title Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
title_full Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
title_fullStr Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
title_full_unstemmed Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
title_short Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
title_sort postmitotic g1 phase survivin drives mitogen-independent cell division of b lymphocytes
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170024/
https://www.ncbi.nlm.nih.gov/pubmed/35476510
http://dx.doi.org/10.1073/pnas.2115567119
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