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Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes
B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show that in contrast to the canonical view that G1 progression signals are essential after mitosis to reenter S phase, B lymphocytes sustain sev...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170024/ https://www.ncbi.nlm.nih.gov/pubmed/35476510 http://dx.doi.org/10.1073/pnas.2115567119 |
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author | Singh, Amit Spitzer, Matthew H. Joy, Jaimy P. Kaileh, Mary Qiu, Xiang Nolan, Garry P. Sen, Ranjan |
author_facet | Singh, Amit Spitzer, Matthew H. Joy, Jaimy P. Kaileh, Mary Qiu, Xiang Nolan, Garry P. Sen, Ranjan |
author_sort | Singh, Amit |
collection | PubMed |
description | B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show that in contrast to the canonical view that G1 progression signals are essential after mitosis to reenter S phase, B lymphocytes sustain several rounds of mitogen-independent cell division following the first mitosis. Such division appears to be driven by unique characteristics of the postmitotic G1 phase that has features of S and G2/M phases. Birc5 (survivin), a protein associated with chromosome segregation in G2/M, is expressed in the G1 phase of divided B cells and is necessary for mitogen-independent divisions. The partially active G1 phase and propensity for apoptosis inherited after each division may underlie rapid proliferation and cell death, which are hallmarks of B cell proliferative responses. |
format | Online Article Text |
id | pubmed-9170024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-91700242022-06-07 Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes Singh, Amit Spitzer, Matthew H. Joy, Jaimy P. Kaileh, Mary Qiu, Xiang Nolan, Garry P. Sen, Ranjan Proc Natl Acad Sci U S A Biological Sciences B and T lymphocytes of the adaptive immune system undergo proliferative bursts to generate pools of antigen-specific cells for effective immunity. Here we show that in contrast to the canonical view that G1 progression signals are essential after mitosis to reenter S phase, B lymphocytes sustain several rounds of mitogen-independent cell division following the first mitosis. Such division appears to be driven by unique characteristics of the postmitotic G1 phase that has features of S and G2/M phases. Birc5 (survivin), a protein associated with chromosome segregation in G2/M, is expressed in the G1 phase of divided B cells and is necessary for mitogen-independent divisions. The partially active G1 phase and propensity for apoptosis inherited after each division may underlie rapid proliferation and cell death, which are hallmarks of B cell proliferative responses. National Academy of Sciences 2022-04-27 2022-05-03 /pmc/articles/PMC9170024/ /pubmed/35476510 http://dx.doi.org/10.1073/pnas.2115567119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Singh, Amit Spitzer, Matthew H. Joy, Jaimy P. Kaileh, Mary Qiu, Xiang Nolan, Garry P. Sen, Ranjan Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes |
title | Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes |
title_full | Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes |
title_fullStr | Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes |
title_full_unstemmed | Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes |
title_short | Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes |
title_sort | postmitotic g1 phase survivin drives mitogen-independent cell division of b lymphocytes |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170024/ https://www.ncbi.nlm.nih.gov/pubmed/35476510 http://dx.doi.org/10.1073/pnas.2115567119 |
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