The mechanism for ligand activation of the GPCR–G protein complex

G protein–coupled receptors (GPCRs) activate cellular responses ranging from odorants to neurotransmitters. Binding an agonist leads to activation of a heterotrimeric G protein (GP) that stimulates external signaling. Unfortunately, the mechanism remains unknown. We show for 15 class A GPCRs, includ...

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Detalles Bibliográficos
Autores principales: Mafi, Amirhossein, Kim, Soo-Kyung, Goddard, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170043/
https://www.ncbi.nlm.nih.gov/pubmed/35452328
http://dx.doi.org/10.1073/pnas.2110085119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170043/
https://www.ncbi.nlm.nih.gov/pubmed/35452328
http://dx.doi.org/10.1073/pnas.2110085119

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