Agonists of prostaglandin E(2) receptors as potential first in class treatment for nephronophthisis and related ciliopathies

Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging to the ciliopathy disorders and known as the most common cause of hereditary end-stage renal disease in children. Yet, no curative treatment is available. The major gene, NPHP1, encodes a protein playing key fu...

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Detalles Bibliográficos
Autores principales: Garcia, Hugo, Serafin, Alice S., Silbermann, Flora, Porée, Esther, Viau, Amandine, Mahaut, Clémentine, Billot, Katy, Birgy, Éléonore, Garfa-Traore, Meriem, Roy, Stéphanie, Ceccarelli, Salomé, Mehraz, Manon, Rodriguez, Pamela C., Deleglise, Bérangère, Furio, Laetitia, Jabot-Hanin, Fabienne, Cagnard, Nicolas, Del Nery, Elaine, Fila, Marc, Sin-Monnot, Soraya, Antignac, Corinne, Lyonnet, Stanislas, Krug, Pauline, Salomon, Rémi, Annereau, Jean-Philippe, Benmerah, Alexandre, Delous, Marion, Briseño-Roa, Luis, Saunier, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170064/
https://www.ncbi.nlm.nih.gov/pubmed/35482924
http://dx.doi.org/10.1073/pnas.2115960119

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