Convergent total synthesis of (+)-calcipotriol: A scalable, modular approach to vitamin D analogs

A convergent approach for the total synthesis of calcipotriol (brand name: Dovonex), a proven vitamin D analog used for the treatment of psoriasis, and medicinally relevant synthetic analogs is described. A complete approach, not wedded to semisynthesis, toward both the A-ring and CD-ring is reporte...

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Detalles Bibliográficos
Autores principales: Gu, Jieyu, Rodriguez, Kevin X., Kanda, Yuzuru, Yang, Shenghua, Ociepa, Michal, Wilke, Henrik, Abrishami, Arteen V., Jørgensen, Lars, Skak-Nielsen, Tine, Chen, Jason S., Baran, Phil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170165/
https://www.ncbi.nlm.nih.gov/pubmed/35476519
http://dx.doi.org/10.1073/pnas.2200814119

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