Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

Two epigenetic pathways of transcriptional repression, DNA methylation and polycomb repressive complex 2 (PRC2), are known to regulate neuronal development and function. However, their respective contributions to brain maturation are unknown. We found that conditional loss of the de novo DNA methylt...

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Detalles Bibliográficos
Autores principales: Li, Junhao, Pinto-Duarte, Antonio, Zander, Mark, Cuoco, Michael S, Lai, Chi-Yu, Osteen, Julia, Fang, Linjing, Luo, Chongyuan, Lucero, Jacinta D, Gomez-Castanon, Rosa, Nery, Joseph R, Silva-Garcia, Isai, Pang, Yan, Sejnowski, Terrence J, Powell, Susan B, Ecker, Joseph R, Mukamel, Eran A, Behrens, M Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170249/
https://www.ncbi.nlm.nih.gov/pubmed/35604009
http://dx.doi.org/10.7554/eLife.66909

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