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Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?

Environmental selenium (Se) distribution in the US is uneven, yet US residents appear to have a relatively narrow range of serum Se concentrations, according to the NHANES III survey data; this is probably due to the modern food-distribution system. In the US, Se concentration in alfalfa leaves has...

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Autores principales: Zhang, Jinsong, Will Taylor, Ethan, Bennett, Kate, Rayman, Margaret P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association for Gondwana Research. Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170275/
https://www.ncbi.nlm.nih.gov/pubmed/35692874
http://dx.doi.org/10.1016/j.gr.2022.05.017
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author Zhang, Jinsong
Will Taylor, Ethan
Bennett, Kate
Rayman, Margaret P.
author_facet Zhang, Jinsong
Will Taylor, Ethan
Bennett, Kate
Rayman, Margaret P.
author_sort Zhang, Jinsong
collection PubMed
description Environmental selenium (Se) distribution in the US is uneven, yet US residents appear to have a relatively narrow range of serum Se concentrations, according to the NHANES III survey data; this is probably due to the modern food-distribution system. In the US, Se concentration in alfalfa leaves has been used as a proxy for regional Se exposure (low, medium or high, corresponding to ≤ 0.05, 0.06–0.10 and ≥ 0.11 ppm respectively). Se in plants, soil, water, and bacteria can be transformed into volatile dimethyldiselenide, which can be inhaled and excreted via the lung. Hence, pulmonary Se exposure may be different in states with different atmospheric Se levels. We found a significantly higher death rate from COVID-19 in low-Se states than in medium-Se or high-Se states, though the case densities of these states were not significantly different. Because inhaled dimethyldiselenide is a potent inducer of nuclear-factor erythroid 2 p45-related factor 2 (Nrf2), exposure to higher atmospheric dimethyldiselenide may increase Nrf2-dependent antioxidant defences, reducing the activation of NFκB by SARS-CoV-2 in the lung, thereby decreasing cytokine activation and COVID-19 severity. Atmospheric dimethyldiselenide may thereby play a role in COVID-19 mortality, although the extent of its involvement is unclear.
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spelling pubmed-91702752022-06-07 Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality? Zhang, Jinsong Will Taylor, Ethan Bennett, Kate Rayman, Margaret P. Gondwana Res Article Environmental selenium (Se) distribution in the US is uneven, yet US residents appear to have a relatively narrow range of serum Se concentrations, according to the NHANES III survey data; this is probably due to the modern food-distribution system. In the US, Se concentration in alfalfa leaves has been used as a proxy for regional Se exposure (low, medium or high, corresponding to ≤ 0.05, 0.06–0.10 and ≥ 0.11 ppm respectively). Se in plants, soil, water, and bacteria can be transformed into volatile dimethyldiselenide, which can be inhaled and excreted via the lung. Hence, pulmonary Se exposure may be different in states with different atmospheric Se levels. We found a significantly higher death rate from COVID-19 in low-Se states than in medium-Se or high-Se states, though the case densities of these states were not significantly different. Because inhaled dimethyldiselenide is a potent inducer of nuclear-factor erythroid 2 p45-related factor 2 (Nrf2), exposure to higher atmospheric dimethyldiselenide may increase Nrf2-dependent antioxidant defences, reducing the activation of NFκB by SARS-CoV-2 in the lung, thereby decreasing cytokine activation and COVID-19 severity. Atmospheric dimethyldiselenide may thereby play a role in COVID-19 mortality, although the extent of its involvement is unclear. International Association for Gondwana Research. Published by Elsevier B.V. 2023-02 2022-06-06 /pmc/articles/PMC9170275/ /pubmed/35692874 http://dx.doi.org/10.1016/j.gr.2022.05.017 Text en © 2022 International Association for Gondwana Research. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Jinsong
Will Taylor, Ethan
Bennett, Kate
Rayman, Margaret P.
Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?
title Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?
title_full Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?
title_fullStr Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?
title_full_unstemmed Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?
title_short Does atmospheric dimethyldiselenide play a role in reducing COVID-19 mortality?
title_sort does atmospheric dimethyldiselenide play a role in reducing covid-19 mortality?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170275/
https://www.ncbi.nlm.nih.gov/pubmed/35692874
http://dx.doi.org/10.1016/j.gr.2022.05.017
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