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Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis
BACKGROUND: Sleep disturbances and benzodiazepine (BZD)/Z-drug use are common in patients with bipolar disorder (BD). OBJECTIVE: To investigate the short- and long-term effects of BZD/Z-drug use during acute affective episode. METHODS: Participants diagnosed with BD as well as sleep disturbance chos...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170399/ https://www.ncbi.nlm.nih.gov/pubmed/35677635 http://dx.doi.org/10.1155/2022/6799898 |
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author | Chen, Yiming Wang, Fan Cui, Lvchun Huang, Haijing Kong, Shuqi Qian, Nuoshi Zhang, Mengke Lyu, Dongbin Wang, Meiti Liu, Xiaohua Cao, Lan Fang, Yiru Hong, Wu |
author_facet | Chen, Yiming Wang, Fan Cui, Lvchun Huang, Haijing Kong, Shuqi Qian, Nuoshi Zhang, Mengke Lyu, Dongbin Wang, Meiti Liu, Xiaohua Cao, Lan Fang, Yiru Hong, Wu |
author_sort | Chen, Yiming |
collection | PubMed |
description | BACKGROUND: Sleep disturbances and benzodiazepine (BZD)/Z-drug use are common in patients with bipolar disorder (BD). OBJECTIVE: To investigate the short- and long-term effects of BZD/Z-drug use during acute affective episode. METHODS: Participants diagnosed with BD as well as sleep disturbance chose BZDs/Z-drugs or not at will. Manic and depressive symptoms were assessed by Mental Disorders Questionnaire (MDQ) and Quick Inventory of Depressive Symptoms (QIDS) as self-reporting surveys. The participants were assessed by trained evaluators at baseline and months 1, 3, 6, and 9. RESULTS: 61 patients with BD combined sleep disturbances were studied. At baseline, patients who used BZDs/Z-drugs had more amount of mood stabilizers (p = 0.038), other psychotropic medications (p = 0.040), and more risk of suicide attempt (p = 0.019). The BZD/Z-drug group had a significantly higher QIDS reductive ratio as compared with the no BZD/Z-drug group at month 1; no significant differences in the variability of MDQ, QIDS reductive ratio, or recurrence rate were found between these two groups at baseline, month 1, month 3, month 6, or month 9. CONCLUSIONS: During acute affective episode, patients with BD combined sleep disturbance who took BZDs/Z-drugs tended to use more amount of mood stabilizers. Polytherapy of BZDs/Z-drugs or other psychiatric drugs could increase suicide attempt during an acute affective episode. BZD/Z-drug use, however, had a significant effect on helping depressive symptoms alleviate during affective period. |
format | Online Article Text |
id | pubmed-9170399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91703992022-06-07 Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis Chen, Yiming Wang, Fan Cui, Lvchun Huang, Haijing Kong, Shuqi Qian, Nuoshi Zhang, Mengke Lyu, Dongbin Wang, Meiti Liu, Xiaohua Cao, Lan Fang, Yiru Hong, Wu Dis Markers Research Article BACKGROUND: Sleep disturbances and benzodiazepine (BZD)/Z-drug use are common in patients with bipolar disorder (BD). OBJECTIVE: To investigate the short- and long-term effects of BZD/Z-drug use during acute affective episode. METHODS: Participants diagnosed with BD as well as sleep disturbance chose BZDs/Z-drugs or not at will. Manic and depressive symptoms were assessed by Mental Disorders Questionnaire (MDQ) and Quick Inventory of Depressive Symptoms (QIDS) as self-reporting surveys. The participants were assessed by trained evaluators at baseline and months 1, 3, 6, and 9. RESULTS: 61 patients with BD combined sleep disturbances were studied. At baseline, patients who used BZDs/Z-drugs had more amount of mood stabilizers (p = 0.038), other psychotropic medications (p = 0.040), and more risk of suicide attempt (p = 0.019). The BZD/Z-drug group had a significantly higher QIDS reductive ratio as compared with the no BZD/Z-drug group at month 1; no significant differences in the variability of MDQ, QIDS reductive ratio, or recurrence rate were found between these two groups at baseline, month 1, month 3, month 6, or month 9. CONCLUSIONS: During acute affective episode, patients with BD combined sleep disturbance who took BZDs/Z-drugs tended to use more amount of mood stabilizers. Polytherapy of BZDs/Z-drugs or other psychiatric drugs could increase suicide attempt during an acute affective episode. BZD/Z-drug use, however, had a significant effect on helping depressive symptoms alleviate during affective period. Hindawi 2022-05-30 /pmc/articles/PMC9170399/ /pubmed/35677635 http://dx.doi.org/10.1155/2022/6799898 Text en Copyright © 2022 Yiming Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Yiming Wang, Fan Cui, Lvchun Huang, Haijing Kong, Shuqi Qian, Nuoshi Zhang, Mengke Lyu, Dongbin Wang, Meiti Liu, Xiaohua Cao, Lan Fang, Yiru Hong, Wu Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis |
title | Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis |
title_full | Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis |
title_fullStr | Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis |
title_full_unstemmed | Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis |
title_short | Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis |
title_sort | short- and long-term influences of benzodiazepine and z-drug use in patients with bipolar disorder combined sleep disturbance during affective period: a nine-month follow-up analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170399/ https://www.ncbi.nlm.nih.gov/pubmed/35677635 http://dx.doi.org/10.1155/2022/6799898 |
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