ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

Mutations in VPS13C cause early-onset, autosomal recessive Parkinson’s disease (PD). We have established that VPS13C encodes a lipid transfer protein localized to contact sites between the ER and late endosomes/lysosomes. In the current study, we demonstrate that depleting VPS13C in HeLa cells cause...

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Detalles Bibliográficos
Autores principales: Hancock-Cerutti, William, Wu, Zheng, Xu, Peng, Yadavalli, Narayana, Leonzino, Marianna, Tharkeshwar, Arun Kumar, Ferguson, Shawn M., Shadel, Gerald S., De Camilli, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170524/
https://www.ncbi.nlm.nih.gov/pubmed/35657605
http://dx.doi.org/10.1083/jcb.202106046

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