Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Although the immunomodulatory and cytoprotective properties of itaconate have been studied extensively, it is not known whether its naturally occurring isomers mesaconate and citraconate have similar properties. Here, we show that itaconate is partially converted to mesaconate intracellularly and th...

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Detalles Bibliográficos
Autores principales: Chen, F., Elgaher, W. A. M., Winterhoff, M., Büssow, K., Waqas, F. H., Graner, E., Pires-Afonso, Y., Casares Perez, L., de la Vega, L., Sahini, N., Czichon, L., Zobl, W., Zillinger, T., Shehata, M., Pleschka, S., Bähre, H., Falk, C., Michelucci, A., Schuchardt, S., Blankenfeldt, W., Hirsch, A. K. H., Pessler, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170585/
https://www.ncbi.nlm.nih.gov/pubmed/35655026
http://dx.doi.org/10.1038/s42255-022-00577-x

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