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Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role

PTENα and PTENβ (PTENα/β), two long translational variants of phosphatase and tensin homolog on chromosome 10 (PTEN), exert distinct roles from canonical PTEN, including promoting carcinogenesis and accelerating immune-resistant cancer progression. However, their roles in carcinogenesis remain great...

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Detalles Bibliográficos
Autores principales:	Zhang, Cheng, Ma, Hong-Ming, Dong, Shuang-Shu, Zhang, Na, He, Ping, Ge, Meng-Kai, Xia, Li, Yu, Jian-Xiu, Xia, Qiang, Chen, Guo-Qiang, Shen, Shao-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170693/ https://www.ncbi.nlm.nih.gov/pubmed/35668069 http://dx.doi.org/10.1038/s41419-022-04988-2

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