Cargando…

Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts

The prevalence of major neurocognitive disorders is expected to rise over the next 3 decades as the number of adults ≥65 years old increases. Noninvasive screening capable of flagging individuals most at risk of subsequent cognitive decline could trigger closer monitoring and preventive strategies....

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Chengjian, Babiker, Niser, Urbanek, Jacek K., Grossman, Robert L., Huisingh-Scheetz, Megan, Rzhetsky, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170733/
https://www.ncbi.nlm.nih.gov/pubmed/35927250
http://dx.doi.org/10.1038/s41514-022-00087-w
_version_ 1784721501517250560
author Shi, Chengjian
Babiker, Niser
Urbanek, Jacek K.
Grossman, Robert L.
Huisingh-Scheetz, Megan
Rzhetsky, Andrey
author_facet Shi, Chengjian
Babiker, Niser
Urbanek, Jacek K.
Grossman, Robert L.
Huisingh-Scheetz, Megan
Rzhetsky, Andrey
author_sort Shi, Chengjian
collection PubMed
description The prevalence of major neurocognitive disorders is expected to rise over the next 3 decades as the number of adults ≥65 years old increases. Noninvasive screening capable of flagging individuals most at risk of subsequent cognitive decline could trigger closer monitoring and preventive strategies. In this study, we used free-living accelerometry data to forecast cognitive decline within 1- or 5-years in older adults without dementia using two cohorts. The first cohort, recruited in the south side of Chicago, wore hip accelerometers for 7 continuous days. The second cohort, nationally recruited, wore wrist accelerometers continuously for 72 h. Separate classifier models forecasted 1-year cognitive decline with over 85% accuracy using hip data and forecasted 5-year cognitive decline with nearly 70% accuracy using wrist data, significant improvements compared to demographics and comorbidities alone. The proposed models are readily translatable to clinical practices serving ageing populations.
format Online
Article
Text
id pubmed-9170733
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-91707332022-06-07 Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts Shi, Chengjian Babiker, Niser Urbanek, Jacek K. Grossman, Robert L. Huisingh-Scheetz, Megan Rzhetsky, Andrey NPJ Aging Article The prevalence of major neurocognitive disorders is expected to rise over the next 3 decades as the number of adults ≥65 years old increases. Noninvasive screening capable of flagging individuals most at risk of subsequent cognitive decline could trigger closer monitoring and preventive strategies. In this study, we used free-living accelerometry data to forecast cognitive decline within 1- or 5-years in older adults without dementia using two cohorts. The first cohort, recruited in the south side of Chicago, wore hip accelerometers for 7 continuous days. The second cohort, nationally recruited, wore wrist accelerometers continuously for 72 h. Separate classifier models forecasted 1-year cognitive decline with over 85% accuracy using hip data and forecasted 5-year cognitive decline with nearly 70% accuracy using wrist data, significant improvements compared to demographics and comorbidities alone. The proposed models are readily translatable to clinical practices serving ageing populations. Nature Publishing Group UK 2022-06-06 /pmc/articles/PMC9170733/ /pubmed/35927250 http://dx.doi.org/10.1038/s41514-022-00087-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shi, Chengjian
Babiker, Niser
Urbanek, Jacek K.
Grossman, Robert L.
Huisingh-Scheetz, Megan
Rzhetsky, Andrey
Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
title Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
title_full Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
title_fullStr Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
title_full_unstemmed Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
title_short Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
title_sort free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170733/
https://www.ncbi.nlm.nih.gov/pubmed/35927250
http://dx.doi.org/10.1038/s41514-022-00087-w
work_keys_str_mv AT shichengjian freelivingwristandhipaccelerometryforecastcognitivedeclineamongolderadultswithoutdementiaover1or5yearsintwodistinctobservationalcohorts
AT babikerniser freelivingwristandhipaccelerometryforecastcognitivedeclineamongolderadultswithoutdementiaover1or5yearsintwodistinctobservationalcohorts
AT urbanekjacekk freelivingwristandhipaccelerometryforecastcognitivedeclineamongolderadultswithoutdementiaover1or5yearsintwodistinctobservationalcohorts
AT grossmanrobertl freelivingwristandhipaccelerometryforecastcognitivedeclineamongolderadultswithoutdementiaover1or5yearsintwodistinctobservationalcohorts
AT huisinghscheetzmegan freelivingwristandhipaccelerometryforecastcognitivedeclineamongolderadultswithoutdementiaover1or5yearsintwodistinctobservationalcohorts
AT rzhetskyandrey freelivingwristandhipaccelerometryforecastcognitivedeclineamongolderadultswithoutdementiaover1or5yearsintwodistinctobservationalcohorts