Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage

Type 1 diabetes (T1D) is an autoimmune disorder defined by CD8 T cell–mediated destruction of pancreatic β cells. We have previously shown that diabetogenic CD8 T cells in the islets of non-obese diabetic mice are phenotypically heterogeneous, but clonal heterogeneity remains relatively unexplored....

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Detalles Bibliográficos
Autores principales: Kasmani, Moujtaba Y, Ciecko, Ashley E, Brown, Ashley K, Petrova, Galina, Gorski, Jack, Chen, Yi-Guang, Cui, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170949/
https://www.ncbi.nlm.nih.gov/pubmed/35667687
http://dx.doi.org/10.26508/lsa.202201503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170949/
https://www.ncbi.nlm.nih.gov/pubmed/35667687
http://dx.doi.org/10.26508/lsa.202201503

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