Cargando…

Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage

Type 1 diabetes (T1D) is an autoimmune disorder defined by CD8 T cell–mediated destruction of pancreatic β cells. We have previously shown that diabetogenic CD8 T cells in the islets of non-obese diabetic mice are phenotypically heterogeneous, but clonal heterogeneity remains relatively unexplored....

Descripción completa

Detalles Bibliográficos
Autores principales:	Kasmani, Moujtaba Y, Ciecko, Ashley E, Brown, Ashley K, Petrova, Galina, Gorski, Jack, Chen, Yi-Guang, Cui, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170949/ https://www.ncbi.nlm.nih.gov/pubmed/35667687 http://dx.doi.org/10.26508/lsa.202201503

Ejemplares similares

Inhibiting BRD4 to generate BETter T cell memory
por: Kasmani, Moujtaba Y., et al.
Publicado: (2021)

Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8(+) T Cells
por: Chen, Yao, et al.
Publicado: (2021)

Autoreactive Effector/Memory CD4(+) and CD8(+) T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage
por: Diz, Ramiro, et al.
Publicado: (2012)

Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection
por: Topchyan, Paytsar, et al.
Publicado: (2022)

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases
por: Chen, Yi-Guang, et al.
Publicado: (2014)

Delineating the transcriptional landscape and clonal diversity of virus-specific CD4(+) T cells during chronic viral infection
por: Zander, Ryan, et al.
Publicado: (2022)

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice
por: Alriyami, Maha, et al.
Publicado: (2019)

Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines
por: Stancill, Jennifer S, et al.
Publicado: (2021)

Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells
por: Stancill, Jennifer S, et al.
Publicado: (2021)

UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice
por: Chen, Yi-Guang, et al.
Publicado: (2020)

Single-cell immune profiling reveals a developmentally distinct CD4(+) GM-CSF(+) T-cell lineage that induces GI tract GVHD
por: Piper, Clint, et al.
Publicado: (2022)

Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection
por: Volberding, Peter J., et al.
Publicado: (2021)

Production of autoreactive I region-restricted T cell hybridomas
Publicado: (1982)

MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice
por: Zhang, Mingfeng, et al.
Publicado: (2018)

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse
por: Lund, Maria E., et al.
Publicado: (2014)

High-Throughput Sequencing of Islet-Infiltrating Memory CD4(+) T Cells Reveals a Similar Pattern of TCR Vβ Usage in Prediabetic and Diabetic NOD Mice
por: Marrero, Idania, et al.
Publicado: (2013)

Harnessing the IL-21-BATF Pathway in the CD8(+) T Cell Anti-Tumor Response
por: Topchyan, Paytsar, et al.
Publicado: (2021)

Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming
por: Hu, Xin, et al.
Publicado: (2019)

Induction of autoreactive B cells allows priming of autoreactive T cells
Publicado: (1991)

The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope
Publicado: (1988)

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?
por: Souter, Michael N. T., et al.
Publicado: (2020)

Diverse Mucosal-Associated Invariant TCR Usage in HIV Infection
por: Trivedi, Shubhanshi, et al.
Publicado: (2021)

Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
por: Volpe, Joseph M, et al.
Publicado: (2009)

A spatial sequencing atlas of age-induced changes in the lung during influenza infection
por: Kasmani, Moujtaba Y., et al.
Publicado: (2023)

BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology
por: Khatun, Achia, et al.
Publicado: (2023)

Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice
por: Racine, Jeremy, et al.
Publicado: (2011)

Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity
por: Schendel, Dolores J., et al.
Publicado: (2013)

MHC-restricted minimal regulatory circuit initiated by a class II- autoreactive T cell clone
Publicado: (1987)

Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire
por: Khatun, Achia, et al.
Publicado: (2020)

Quantifying Distribution of Flow Cytometric TCR-Vβ Usage with Economic Statistics
por: van der Geest, Kornelis S. M., et al.
Publicado: (2015)

VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins
por: Fischer, Sebastian, et al.
Publicado: (2021)

The secret autoreactivity of B cells
por: Williams, Ruth
Publicado: (2007)

Autoreactivity patterns in rheumatoid arthritis
por: Behrens, S, et al.
Publicado: (2001)

The broad spectrum of pathogenic autoreactivity
por: Santambrogio, Laura, et al.
Publicado: (2022)

The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families
por: Park, Se-Ho, et al.
Publicado: (2001)

Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
por: Lebel, Marie-Ève, et al.
Publicado: (2020)

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice
Publicado: (1994)

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis
por: Sharma, Ravi K., et al.
Publicado: (2021)

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
por: Buckle, Ashley M., et al.
Publicado: (2018)

Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice
por: Wu, Xiaopeng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0hlhid571rjkmir7pbmlkjqi99