Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

• The N-terminal tail of histone H3 is specifically cleaved during EV71 infection. • Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail. • Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interacti...

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Detalles Bibliográficos
Autores principales: Miao, Meng, Deng, Gang, Xiong, Xiaobei, Qiu, Yang, Huang, Wenda, Yuan, Meng, Yu, Fei, Bai, Shimei, Zhou, Xi, Zhao, Xiaolu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170973/
https://www.ncbi.nlm.nih.gov/pubmed/35256288
http://dx.doi.org/10.1016/j.virs.2022.02.006
Descripción
Sumario:• The N-terminal tail of histone H3 is specifically cleaved during EV71 infection. • Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail. • Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.

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