Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies

Transcriptome-wide association studies (TWAS) are popular approaches to test for association between imputed gene expression levels and traits of interest. Here, we propose an integrative method PUMICE (Prediction Using Models Informed by Chromatin conformations and Epigenomics) to integrate 3D geno...

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Detalles Bibliográficos
Autores principales: Khunsriraksakul, Chachrit, McGuire, Daniel, Sauteraud, Renan, Chen, Fang, Yang, Lina, Wang, Lida, Hughey, Jordan, Eckert, Scott, Dylan Weissenkampen, J., Shenoy, Ganesh, Marx, Olivia, Carrel, Laura, Jiang, Bibo, Liu, Dajiang J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171100/
https://www.ncbi.nlm.nih.gov/pubmed/35672318
http://dx.doi.org/10.1038/s41467-022-30956-7

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