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Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units

Nitrous oxide (N(2)O) was found responsible for genetic and reproductive toxicities, whereas it is widely used in paediatric care units where most healthcare providers are women of childbearing age. This motivated investigating occupational overexposure and overexposure factors in several paediatric...

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Autores principales: DENIS, Marie-Agnès, PETE-BONNETON, Charlotte, RICHE, Benjamin, CADOT, Robert, MASSARDIER-PILONCHERY, Amélie, IWAZ, Jean, CHARBOTEL, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Occupational Safety and Health, Japan 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171129/
https://www.ncbi.nlm.nih.gov/pubmed/34690255
http://dx.doi.org/10.2486/indhealth.2021-0067
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author DENIS, Marie-Agnès
PETE-BONNETON, Charlotte
RICHE, Benjamin
CADOT, Robert
MASSARDIER-PILONCHERY, Amélie
IWAZ, Jean
CHARBOTEL, Barbara
author_facet DENIS, Marie-Agnès
PETE-BONNETON, Charlotte
RICHE, Benjamin
CADOT, Robert
MASSARDIER-PILONCHERY, Amélie
IWAZ, Jean
CHARBOTEL, Barbara
author_sort DENIS, Marie-Agnès
collection PubMed
description Nitrous oxide (N(2)O) was found responsible for genetic and reproductive toxicities, whereas it is widely used in paediatric care units where most healthcare providers are women of childbearing age. This motivated investigating occupational overexposure and overexposure factors in several paediatric hospital units. A cross-sectional study was carried out in seven healthcare units. On each of 34 healthcare providers, air samples were extracted (portable pumps and Tedlar(®) bags) and N(2)O quantified (gas chromatography, pulsed discharge ionization detection, and infrared spectrometry). The data allowed calculating mean instantaneous exposures. The mean instantaneous exposure was: i) four times higher in closed vs. open treatment rooms; ii) two times higher in case of use vs. non-use of N(2)O; iii) significantly higher in junior vs. senior healthcare providers (by 12%); and, iv) higher during presumably short vs. presumably long procedures (by 20%). Overexposures to N(2)O were mainly seen in the emergency unit and in day hospitals for thoracic/abdominal diseases and nephrology. Overexposures were frequent during short-duration procedures; among 88 N(2)O measurements, 77 (87.5%) exceeded the 200 ppm threshold over 15 minutes. The overexposures call for dedicated treatment rooms (with adequate equipment and ventilation), more efficient anaesthetic practices, appropriate training, and regular checks.
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spelling pubmed-91711292022-06-14 Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units DENIS, Marie-Agnès PETE-BONNETON, Charlotte RICHE, Benjamin CADOT, Robert MASSARDIER-PILONCHERY, Amélie IWAZ, Jean CHARBOTEL, Barbara Ind Health Field Report Nitrous oxide (N(2)O) was found responsible for genetic and reproductive toxicities, whereas it is widely used in paediatric care units where most healthcare providers are women of childbearing age. This motivated investigating occupational overexposure and overexposure factors in several paediatric hospital units. A cross-sectional study was carried out in seven healthcare units. On each of 34 healthcare providers, air samples were extracted (portable pumps and Tedlar(®) bags) and N(2)O quantified (gas chromatography, pulsed discharge ionization detection, and infrared spectrometry). The data allowed calculating mean instantaneous exposures. The mean instantaneous exposure was: i) four times higher in closed vs. open treatment rooms; ii) two times higher in case of use vs. non-use of N(2)O; iii) significantly higher in junior vs. senior healthcare providers (by 12%); and, iv) higher during presumably short vs. presumably long procedures (by 20%). Overexposures to N(2)O were mainly seen in the emergency unit and in day hospitals for thoracic/abdominal diseases and nephrology. Overexposures were frequent during short-duration procedures; among 88 N(2)O measurements, 77 (87.5%) exceeded the 200 ppm threshold over 15 minutes. The overexposures call for dedicated treatment rooms (with adequate equipment and ventilation), more efficient anaesthetic practices, appropriate training, and regular checks. National Institute of Occupational Safety and Health, Japan 2021-10-25 2022-05 /pmc/articles/PMC9171129/ /pubmed/34690255 http://dx.doi.org/10.2486/indhealth.2021-0067 Text en ©2022 National Institute of Occupational Safety and Health https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Field Report
DENIS, Marie-Agnès
PETE-BONNETON, Charlotte
RICHE, Benjamin
CADOT, Robert
MASSARDIER-PILONCHERY, Amélie
IWAZ, Jean
CHARBOTEL, Barbara
Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
title Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
title_full Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
title_fullStr Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
title_full_unstemmed Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
title_short Exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
title_sort exposure of paediatric healthcare personnel to nitrous oxide in paediatric care units
topic Field Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171129/
https://www.ncbi.nlm.nih.gov/pubmed/34690255
http://dx.doi.org/10.2486/indhealth.2021-0067
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