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Globin vector regulatory elements are active in early hematopoietic progenitor cells

The globin genes are archetypal tissue-specific genes that are silent in most tissues but for late-stage erythroblasts upon terminal erythroid differentiation. The transcriptional activation of the β-globin gene is under the control of proximal and distal regulatory elements located on chromosome 11...

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Detalles Bibliográficos
Autores principales:	Cabriolu, Annalisa, Odak, Ashlesha, Zamparo, Lee, Yuan, Han, Leslie, Christina S., Sadelain, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171148/ https://www.ncbi.nlm.nih.gov/pubmed/35247584 http://dx.doi.org/10.1016/j.ymthe.2022.02.028

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