Immunodepletion of MDSC by AMV564, a novel bivalent, bispecific CD33/CD3 T cell engager, ex vivo in MDS and melanoma

We have reported previously that CD33(hi) myeloid-derived suppressor cells (MDSCs) play a direct role in the pathogenesis of myelodysplastic syndromes (MDSs) and that their sustained activation contributes to hematopoietic and immune impairment, including modulation of PD1/PDL1. MDSCs can also limit...

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Detalles Bibliográficos
Autores principales: Cheng, Pingyan, Chen, Xianghong, Dalton, Robert, Calescibetta, Alexandra, So, Tina, Gilvary, Danielle, Ward, Grace, Smith, Victoria, Eckard, Sterling, Fox, Judith A., Guenot, Jeanmarie, Markowitz, Joseph, Cleveland, John L., Wright, Kenneth L., List, Alan F., Wei, Sheng, Eksioglu, Erika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171150/
https://www.ncbi.nlm.nih.gov/pubmed/35150889
http://dx.doi.org/10.1016/j.ymthe.2022.02.005

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