Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

ETV6::RUNX1 is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL). In Mexico, its prevalence is low in comparison with Caucasian populations. We developed a novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a...

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Detalles Bibliográficos
Autores principales: Mata-Rocha, Minerva, Rangel-López, Angelica, Jimenez-Hernandez, Elva, Nuñez-Enríquez, Juan Carlos, Morales-Castillo, Blanca Angélica, Sánchez-Escobar, Norberto, Sepúlveda-Robles, Omar Alejandro, Bravata-Alcántara, Juan Carlos, Nájera-Cortés, Alan Steve, Pérez-Saldivar, María Luisa, Flores-Lujano, Janet, Duarte-Rodríguez, David Aldebarán, Oviedo de Anda, Norma Angélica, Romero Tlalolini, Maria de los Angeles, Alaez Verson, Carmen, Martín-Trejo, Jorge Alfonso, Muñoz Medina, Jose Esteban, Gonzalez-Bonilla, Cesar Raul, Hernandez Cueto, Maria de los Angeles, Bekker-Méndez, VC., Jiménez-Morales, Silvia, Medina-Sansón, Aurora, Amador-Sánchez, Raquel, Peñaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Cortés-Herrera, Beatriz, Flores-Villegas, Luz Victoria, Merino-Pasaye, Laura Elizabeth, Gutierrez-Rivera, Maria de Lourdes, Velazquez-Aviña, Martha Margarita, Santillan-Juarez, Jessica Denisse, Gurrola-Silva, Alma, Hernández Echáurregui, Gabriela Alicia, Hidalgo-Miranda, Alfredo, Arellano Galindo, José, Rosas-Vargas, Haydeé, Mejía-Aranguré, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171364/
https://www.ncbi.nlm.nih.gov/pubmed/35685921
http://dx.doi.org/10.3389/fped.2022.837656
Descripción
Sumario:ETV6::RUNX1 is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL). In Mexico, its prevalence is low in comparison with Caucasian populations. We developed a novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a cohort of Hispanic children with ALL from Mexico City. The prevalence of common fusion gene transcripts was as follows: TCF3::PBX1 7.7%; BCR::ABL1p(190) 3.3%; and KMT2A::AFF1 2.8%, and ETV6::RUNX1was observed with low prevalence (10.5%) in comparison to that reported for developed countries. This is consistent with previous findings on Mexican children with ALL and similar to those reported on children from Hispanic populations. The confirmation of a low prevalence of ETV6::RUNX1 in children of a Hispanic origin represents an advancement in the description of genetic factors of ALL in these populations.

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