Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens

De novo immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a major challenge. While focus has been largely on cytotoxic cell-mediated tumor eradication, B-cells and the antibodies they produce als...

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Detalles Bibliográficos
Autores principales: Su, Hsuan, Imai, Kazuhiro, Jia, Wei, Li, Zhiguo, DiCioccio, Rachel A., Serody, Jonathan S., Poe, Jonathan C., Chen, Benny J., Doan, Phuong L., Sarantopoulos, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171395/
https://www.ncbi.nlm.nih.gov/pubmed/35686131
http://dx.doi.org/10.3389/fimmu.2022.865486

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