An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer

Chemotherapy resistance and peculiar tumor microenvironment, which diminish or mitigate the effects of therapies, make pancreatic cancer one of the deadliest malignancies to manage and treat. Advanced immunotherapies are under consideration intending to ameliorate the overall patient survival rate i...

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Autores principales: Nisar, Maryum, Paracha, Rehan Zafar, Adil, Sidra, Qureshi, Sumair Naseem, Janjua, Hussnain Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171400/
https://www.ncbi.nlm.nih.gov/pubmed/35686109
http://dx.doi.org/10.3389/fonc.2022.875188
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author Nisar, Maryum
Paracha, Rehan Zafar
Adil, Sidra
Qureshi, Sumair Naseem
Janjua, Hussnain Ahmed
author_facet Nisar, Maryum
Paracha, Rehan Zafar
Adil, Sidra
Qureshi, Sumair Naseem
Janjua, Hussnain Ahmed
author_sort Nisar, Maryum
collection PubMed
description Chemotherapy resistance and peculiar tumor microenvironment, which diminish or mitigate the effects of therapies, make pancreatic cancer one of the deadliest malignancies to manage and treat. Advanced immunotherapies are under consideration intending to ameliorate the overall patient survival rate in pancreatic cancer. Oncolytic viruses therapy is a new type of immunotherapy in which a virus after infecting and lysis the cancer cell induces/activates patients’ immune response by releasing tumor antigen in the blood. The current review covers the pathways and molecular ablation that take place in pancreatic cancer cells. It also unfolds the extensive preclinical and clinical trial studies of oncolytic viruses performed and/or undergoing to design an efficacious therapy against pancreatic cancer.
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spelling pubmed-91714002022-06-08 An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer Nisar, Maryum Paracha, Rehan Zafar Adil, Sidra Qureshi, Sumair Naseem Janjua, Hussnain Ahmed Front Oncol Oncology Chemotherapy resistance and peculiar tumor microenvironment, which diminish or mitigate the effects of therapies, make pancreatic cancer one of the deadliest malignancies to manage and treat. Advanced immunotherapies are under consideration intending to ameliorate the overall patient survival rate in pancreatic cancer. Oncolytic viruses therapy is a new type of immunotherapy in which a virus after infecting and lysis the cancer cell induces/activates patients’ immune response by releasing tumor antigen in the blood. The current review covers the pathways and molecular ablation that take place in pancreatic cancer cells. It also unfolds the extensive preclinical and clinical trial studies of oncolytic viruses performed and/or undergoing to design an efficacious therapy against pancreatic cancer. Frontiers Media S.A. 2022-05-24 /pmc/articles/PMC9171400/ /pubmed/35686109 http://dx.doi.org/10.3389/fonc.2022.875188 Text en Copyright © 2022 Nisar, Paracha, Adil, Qureshi and Janjua https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Nisar, Maryum
Paracha, Rehan Zafar
Adil, Sidra
Qureshi, Sumair Naseem
Janjua, Hussnain Ahmed
An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
title An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
title_full An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
title_fullStr An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
title_full_unstemmed An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
title_short An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
title_sort extensive review on preclinical and clinical trials of oncolytic viruses therapy for pancreatic cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171400/
https://www.ncbi.nlm.nih.gov/pubmed/35686109
http://dx.doi.org/10.3389/fonc.2022.875188
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