ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only partly understood. We identify the host metalloprotease ADAM17 as a facilitator of SARS‐CoV‐2 cell entry and the metalloproteas...

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Detalles Bibliográficos
Autores principales: Jocher, Georg, Grass, Vincent, Tschirner, Sarah K, Riepler, Lydia, Breimann, Stephan, Kaya, Tuğberk, Oelsner, Madlen, Hamad, M Sabri, Hofmann, Laura I, Blobel, Carl P, Schmidt‐Weber, Carsten B, Gokce, Ozgun, Jakwerth, Constanze A, Trimpert, Jakob, Kimpel, Janine, Pichlmair, Andreas, Lichtenthaler, Stefan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171409/
https://www.ncbi.nlm.nih.gov/pubmed/35527514
http://dx.doi.org/10.15252/embr.202154305

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