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Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors

Microtubule dynamics is regulated by various cellular proteins and perturbed by small-molecule compounds. To what extent the mechanism of the former resembles that of the latter is an open question. We report here structures of tubulin bound to the PN2-3 domain of CPAP, a protein controlling the len...

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Detalles Bibliográficos
Autores principales:	Campanacci, Valérie, Urvoas, Agathe, Ammar Khodja, Liza, Aumont-Nicaise, Magali, Noiray, Magali, Lachkar, Sylvie, Curmi, Patrick A., Minard, Philippe, Gigant, Benoît
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171608/ https://www.ncbi.nlm.nih.gov/pubmed/35507869 http://dx.doi.org/10.1073/pnas.2120098119

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